Evidence of Copper Nanoparticles and Poly I:C Modulating Cas9 Interaction and Cleavage of COR (Conserved Omicron RNA)

Conserved omicron RNA (COR) is a 40 base long 99.9% conserved sequence in SARS-CoV-2 Omicron variant, predicted to form a stable stem loop, the targeted cleavage of which can be an ideal next step in controlling the spread of variants.The Cas9 enzyme has been traditionally utilized for gene editing and DNA cleavage.Previously Cas9 has been shown to

read more

Determinants of mosaic chromosomal alteration fitness

Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion.These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations 392 cam kit (mCAs).The factors that inf

read more

Short-Run Asset Selection using a Logistic Model

Investors constantly look for significant predictors and accurate models to forecast future results, whose occasional efficacy end up being neutralized by market efficiency.Regardless, such predictors are widely used for seeking better (and more unique) perceptions.This paper aims to investigate to what extent some of the most notorious indicators

read more